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Dihydromyricetin Side Effects On Humans: Are There Any?

By John Lee on

Dihydromyricetin has been used in Asia for thousands of years as a hangover cure and anti-intoxication medicine and is considered safe for humans even in massive doses. In a DHM toxicity study, researchers failed to find any negative side-effects or deaths while giving mice massive doses of up to 22g/kg body weight. 

Acute toxicity tests showed that a single dose of oral SHE up to 22 g/kg did not result in any death or toxic side effects in mice during 14 days' observation.

Conversions from rat to human pharmacology can be estimated using the HED ratio of 16%, giving DHM a safe upper limit dosage of 15.68g for a 70kg person.

We've written extensively about the science of dihydromyricetin and how it acts on the GABA receptors. To put it simply, alcohol activates your GABA receptors which in turn makes you feel relaxed and induces the feeling of being intoxicated. DHM does the reverse and blocks the effect alcohol has on these receptors. So if you're suffering from a condition that affects your GABA receptors – or are taking any medication that affects the GABAgenic system – we recommend you speak to a medical professional before taking dihydromyricetin.

Is Using Dihydromyricetin on Humans a Good Idea?

The general consensus from the science community is that DHM is safe for human use. David Nutt, the former head of the British government's advisory committee on drugs, is confident that the data gathered on the study involving rats would have the same results as human.

“This supports other data that GABA receptors are key in the actions of alcohol and that targeting this interaction is a viable approach to reducing alcohol intake,” says David Nutt."

Liang, a UCLA researcher who conducted the original study on DHM also agreed that DHM would not carry adverse side effects. 

Drink Smarter and Live Better with DHM

DHM is the main ingredient in Flyby. We extract our dihydromyricetin using our proprietary technology to maximize efficacy, purity and bioavailability. We then pair it with other 17 liver-supporting ingredients like Milk Thistle, N-Acetyl-Cysteine, Prickly Pear, Vitamins, Electrolytes and more. The result is a simple, science-backed solution to the post-drinking drag.